群馬大学大学院医学系研究科総合外科学講座

総合外科学講座

消化管外科学分野(胃グループ)

研究

主な研究テーマ
臨床研究
  • 進行胃癌に対する腹腔鏡下胃切除術の妥当性に関する検討
  • ESDにおけるDEILO (Double endoscopic intraluminal operation)の有用性に関する検討
  • 胃癌手術前の栄養状態とoutcomeに関する検討
  • 胃癌手術前の3D血管構築の有用性に関する検討
  • GIST患者のImatinib血中濃度と有効性、有害事象の関連についての検討
  • 腹膜播種陽性または腹腔細胞診陽性の胃癌に対するS-1+パクリタキセル経静脈・腹腔内併用療法の臨床研究
  • 胃癌補助化学療法時に発生する有害事象(口内炎、栄養障害等)に対するラコールの有効性・安全性の検討(無作為化群間比較試験)
  • 食道胃接合部癌に対する縦隔リンパ節および大動脈周囲リンパ節の郭清効果を検討する介入研究
  • 再発又は遠隔転移を有する胃癌におけるニボルマブ投与後の腫瘍免疫応答の生物学的変化に関する前向き観察研究
基礎研究
  • 胃癌におけるTGFBI発現の意義
  • 切除不能、再発胃癌におけるタキサン系抗癌剤治療効果予測マーカーとしてのSTMN1発現の意義
  • 胃癌におけるRAD18発現意義の解明
  • 早期胃癌におけるPD-L1発現に関する免疫組織学的検討
  • 細胞周期抑制因子FBXW7を利用したGIST細胞のイマチニブ、抗癌剤、放射線抵抗性克服を目指して
  • GISTに対するエリブリンの効果に関する基礎的検討
  • 犬における胃切後Roux-en Y再建時の消化管運動
  • 十二指腸切離モデルにおける消化管運動の研究
  • モンゴル伝統漢方薬(Shizhid-6)の消化管運動に対する影響についての検討
  • 犬モデルにおける甲状腺機能亢進/低下時の消化管運動と生理活性物質の関係についての検討

業績

英文論文・著書
  • Nakazawa N et al. Low IRBIT Levels Are Associated With Chemo-resistance in Gastric Cancer Patients. Anticancer Res. 39(8): 4111-6, 2019
  • Toyomasu Y et al. A prospective pilot study of an elemental nutritional supplement for prevention of oral mucositis during S-1 adjuvant chemotherapy for gastric cancer. Surg Oncol. 29: 97-101, 2019
  • Sano A et al. Paget’s disease derived in situ from reserve cell hyperplasia, squamous metaplasia, and squamous cell carcinoma of the esophagogastric junction: a case report. Surg Case Rep. 4: 81, 2018
  • Nakazawa N et al. Examining the risk factors of conversion to open surgery in patients with urgent laparoscopic cholecystectomy. Drug Invention Today. 10: Special Issue 3, 2018
  • Nakazawa N et al. Adult intussusceptions induced by a terminal ileum diverticulum: a case report. Clin Case Rep. 6(4): 674-7, 2018
  • Ogata K,et al. Long-term imatinib treatment for patients with unresectable or recurrent gastrointestinal stromal tumors (GIST). Digestion 97(1): 64-69, 2018
  • Suzuki M, et al.High stromal transforming growth factor β-induced expression is a novel marker of progression and poor prognosis in gastric cancer. J Surg Oncol. 2018 Sep 9. [Epub ahead of print]
  • Toyomasu Y, et al. Comparison of the Physiological Effect of Billroth-I and Roux-en-Y Reconstruction Following Laparoscopic Distal Gastrectomy. Surg Laparosc Endosc Percutan Tech. 2018 Oct; 28(5):328-333.
  • Ogata K, et al. Double endoscopic intraluminal operation (DEILO) for early gastric cancer-Outcome of novel procedure for endoscopic submucosal dissection- Anticancer Res. 37: 343-348. 2017
  • Toyomasu Y, et al. Restration of gastrointestinal motility ameliorates nutritional deficiencies and body weight loss of patients who undergo laparoscopy-assisted proximal gastrectomy. Surg Endosc. Mar; 31(3): 1393-1401. 2017
  • Kogure N, et al. Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis. Anticancer Res. 37:191-196. 2017
  • Bai T, et al. High STMN1 level is associated with chemo-resistance and poor prognosis in gastric cancer patients. Br J Cancer Apr 25; 116(9):1177-1185. 2017
  • Yanoma T, et al. Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70. Oncol Rep Sep;38(3):1500-1506. 2017
  • Kimura A, et al. Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis. World J Gastroenterol. 23(42):7541-7550. 2017
  • Altan B, et al. High Expression of MRE11-RAD50-NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer.
  • Anticancer Res. Oct;36(10):5237-5247. 2016
  • Kimura A, et al.Nuclear heat shock protein 110 expression is associated with poor prognosis and chemotherapy resistance in gastric cancer.
  • Oncotarget. Apr 5;7(14):18415-23. 2016
  • Altan B, et al. Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients. Gastric Cancer. Jul;19(3):789-97. 2016
  • Kimura A, et al. Outcome of laparoscopic gastrectomy with D1 plus lymph node dissection in gastric cancer patients postoperatively diagnosed with locally advanced disease or lymph node metastasis. Surg Endosc. May; 30(5):2090-6. 2016
  • Toyomasu Y et al. Outcomes of patients with early gastric cancer who underwent double endoscopic intraluminal surgery. Surg Endosc. Jan; 30(1):178-83. 2016
  • Fukuchi M et al. Risk Factors for Recurrence After Curative Conversion Surgery for Unresectable Gastric Cancer. Anticancer Res. Nov;35(11):6183-7.2015
  • Fukuchi M et al. Prognostic Role of Conversion Surgery for Unresectable Gastric Cancer. Ann Surg Oncol. Oct; 22(11):3618-24. 2015
  • Suzuki M et al. Curative Resection Following Neoadjuvant Chemotherapy for Advanced Gastric Cancer With Preservation of a Right Gastroepiploic Artery Coronary Artery Bypass Graft: A Case Report. Int Surg. Jun; 100(6):1138-43. 2015
  • Watanabe A, et al. Nesfatin-1 suppresses gastric contractions and inhibits interdigestive migrating contractions in conscious dogs. Dig Dis Sci. Jun;60(6):1595-602. 2015
  • Nakazawa N et al. Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report. Int Surg. 99: 458-62. 2014
  • Ogata K, et al. A multicenter long-term study of imatinib treatment for Japanese patients with unresectable or recurrent gastrointestinal stromal tumors. Journal of Surgical Oncology. Dec;110(8):942-6. 2014
  • Mochiki E et al. Postoperative functional evaluation of gastric tube after laparoscopic proximal gastrectomy for gastric cancer. Anticancer Research. Aug; 34(8):4293-8. 2014
  • Ohno T, et al. The Usefulness and Safety of the Introducer Technique Using a Bumper-Button-Type Device as Compared With the Pull Method for Percutaneous Endoscopic Gastrostomy. Surg Laparosc Endosc Percutan Tech. 2014 Apr 12. [Epub ahead of print]
  • Ando H, et al. Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs. World J Gastroenterol. Nov 14; 20(42):15691-702. 2014
  • Morita H, et al. Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs. World J Gastroenterol. Oct 21; 19(39):6604-12. 2013
  • Altan B, et al. Nuclear karyopherin-α2 expression in primary lesions and metastatic lymph nodes was associated with poor prognosis and progression in gastric cancer. Carcinogenesis. Oct; 34(10):2314-21. 2013
  • Yanai M, et al. Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs. J Gastroenterol. May; 48(5):611-9. 2013
和文論文・著書
  • 緒方杏一、持木彫人、調 憲、桑野博行:迷走神経腹腔枝温存胃切除に必要な局所解剖.臨床外科73(11):58-61,2018
  • 緒方杏一、宗田 真、調 憲:消化管穿孔部閉鎖術. 5年でマスター 消化器外科標準手術 改訂第2 版:488-94,2018
  • 緒方杏一、桑野博行:消化器GIST 進行GISTにおけるイマチニブ治療後手術. 臨床外科72(10)1228-1234, 2017
  • 緒方杏一、矢内充洋、木村明春、生方泰成、高橋研吾、岩松清人、桑野博行:噴門側胃切除術後再建:Circular stapler 腹腔鏡下手術での胃管再建における吻合. 臨床外科72(4)416-419, 2017
  • 高橋研吾、生方泰成、矢内充洋、岩松清人、緒方杏一、桑野博行:術後重大合併症-これだけは知っておきたい緊急処置法 各論 絞扼性イレウス. 臨床外科72(6)699-703, 2017
  • 福地 稔、持木彫人、石畝 亨、緒方杏一、木村明春、小倉俊郎、熊谷洋一、石橋敬一郎、桑野博行、石田秀行:胃癌に対する最新の集学的治療 切除不能進行胃癌に対するconversion治療.消化器外科 39(10): 1385-1392, 2016
  • 森永暢浩、山中崇弘、德田尚子、松本明香、田中成岳、安藤裕之、中里健二、設楽芳範、石崎政利、塚越正章、吉田孝友:胃癌再発による癌性胸水に対して、シスプラチン胸腔内投与が著効している1例.群馬医学 104: 89-92, 2016
  • 国立大学法人 群馬大学
  • 群馬大学医学部附属病院 臨床研修センター
  • National Clinical Database 外科系の専門医制度と連携した症例データベース

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