群馬大学大学院医学系研究科総合外科学講座

総合外科学講座

消化管外科学分野(上部)

研究

主な研究テーマ
臨床研究
  • 食道癌患者における慢性炎症と骨格筋量減少の関連についての研究
  • 食道癌患者における治療前握力と化学療法、化学放射線治療の成績との関連
  • 胸部食道癌対するDCF-RTの長期成績
  • 切除不能進行再発食道癌に対するDNF療法の有効性に関する検討
  • 食道胃接合部癌の臨床病理学的特徴の解析および治療戦略の検討
  • 食道癌におけるFAMT-PET診断の有用性に関する研究
  • 革新的治療ツールを利用した癌微小管ダイナミクス制御による消化管癌の克服
  • 腹腔鏡下胃癌手術における術後合併症のリスク因子の検討
  • 進行・再発胃癌に対するNivolumab療法の治療成績とその臨床病理学的特徴の検討
  • 胃癌Nivolumab使用症例における治療感受性バイオマーカーの研究
  • VOYAGER Study「切除不能進行再発胃癌を対象としたニボルマブ早期導入の有効性と安全性を評価する単群II相試験」
基礎研究
  • 消化管癌に対するリポソーム化microRNAを用いた革新的治療の開発
  • 接着分子コネキシン26に着目した胃癌制御研究
  • 成犬を用いた甲状腺機能における消化管運動と生理活性物質の解析
  • PET検査を利用した食道癌局所免疫状態の評価に関する研究
  • 食道類基底細胞癌の発癌起源に関する研究
  • 放射線照射と腫瘍免疫に関する研究

業績

英文論文・著書
  • Sakai M et al. Docetaxel, cisplatin, and 5-fluorouracil combination chemoradiotherapy for patients with cervical esophageal cancer: a single-center retrospective study. Cancer Chemother Pharmacol. 83(6): 1121-6, 2019
  • Sohda M et al. Evaluation of Surgical Procedures that Affect the Hemodynamics Using the FloTrac System in Esophageal Cancer Patients. In Vivo. 33(4): 1221-6, 2019
  • Sohda M et al. Multidisciplinary Therapy for Locally Advanced Oesophageal Cancer With Special Reference to Surgical Conversion and Salvage. Anticancer Res. 39(6): 3167-75, 2019
  • Sohda M et al. Post-esophagectomy Adjuvant Chemotherapy Benefits Esophageal Cancer Patients. In Vivo. 33(2): 501-6, 2019
  • Miyazaki T et al. Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases. Internal medicine57(16) 2333-2339, 2018
  • Gombodorj N et al. Correlation between high FBXW7 expression in pretreatment biopsy specimens and good response to chemoradiation therapy in patients with locally advanced esophageal cancer: A retrospective study. Journal of surgical oncology 118(1) 101-108, 2018
  • Sakai M et al. Association of Preoperative Nutritional Status with Prognosis in Patients with Esophageal Cancer Undergoing Salvage Esophagectomy. Anticancer research.38(2):933-938,2018
  • Kumakura Yet al. Elucidation of the Anatomical Mechanism of Nodal Skip Metastasis in Superficial Thoracic Esophageal Squamous Cell Carcinoma. Annals of surgical oncology.25:1221-1228,2018
  • Sohda M et al. Utility of double endoscopic intraluminal operation for esophageal cancer. Surgical endoscopy.31(8) :3333-3338,2017
  • Muranushi R et al. Surgical management for achalasia after coronary artery bypass graft using the right gastroepiploic artery: a case report. Surgical case reports 3(1) 27, 2017
  • Saito H et al. Postprandial cardiogenic syncope caused by gastric polyp-induced pyloric obstruction in an elderly woman with a giant hiatal hernia: a case report. Surgical case reports 3(1) 124, 2017
  • Sakai M et al. Impact of the level of anastomosis on reflux esophagitis following esophagectomy with gastric tube reconstruction. World journal of surgery.41(3) :804-809,2017
  • Sohda M et al.18F-FAMT-PET is useful for judging clinical complete response in advanced esophageal cancer patients who have received definitive chemoradiotherapy. International Surgery.2017
  • Hara K et al. Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma. Anticancer research.37(3) :1043-1048,2017
  • Suzuki S et al. High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma. International journal of oncology.50(4) :1184-1190,2017
  • Hadisaputri Y et al.TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma. International journal of oncology.50(3) :1002-1010,2017
  • Sohda M et al. Clinical significance of salvage esophagectomy for patients with esophageal cancer and factors of influencing long-term survival. Anticancer research.37(9) :5045-5051,2017
  • Sohda M et al.18F-FAMT PET Is Useful to Distinguish between Specific Uptake and Nonspecific Uptake Compared to 18F-Flourodeoxyglucose Position Emission Tomography in Esophageal Cancer Patients. Digestive surgery. 35:383–388,2017
  • Kumakura Y et al. Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma. Cancer science.108(11:)2149-2155,2017
  • Honjo H et al. Clinical significance and phenotype of MTA1 expression in esophageal squamous cell carcinoma. Anticancer research.37(8) :4147-4155,2017
  • Yokobori T et al. Intestinal epithelial culture under an air-liquid interface: a tool for studying human and mouse esophagi. Diseases of the Esophagus.29(7) :843-847,2016
  • Ozawa D et al. TGFBI expression in cancer stromal cells is associated with poor prognosis and hematogenous recurrence in esophageal squamous cell carcinoma. Annals of surgical oncology.23(1) :282-289,2016
  • Nakajima M et al. An Absolute Standardized Uptake Value Is More Useful than the Decreased Rate of Uptake of FDG-PET to Predict Responses to Neoadjuvant Chemoradiotherapy for Esophageal Cancer. Open Journal of Gastroenterology.6(11) :373,2016
  • Miyazaki T et al. Prognostic significance of inflammatory and nutritional parameters in patients with esophageal cancer. Anticancer research.36(12) :6557-6562,2016
  • Altan B et al. Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients. Gastric Cancer.19(3) :789-797,2016
  • Sano A et al. Clinical significance of [18F]-fluoro-deoxy-glucose positron emission tomography/computed tomography in patients with primary malignant melanoma of the esophagus: report of three cases.Esophagus.13(3) :311-316,2016
  • Watanabe T et al. Resection of an esophageal schwannoma with thoracoscopic surgery: a case report. Surgical case reports.2(1) :127,2016
  • Sakai M et al. Endoscopic therapy for esophageal cancer. Kyobu geka. The Japanese journal of thoracic surgery.69(8) :718-723,2016
  • Nakajima M et al. Significant relationship between preoperative serum concentration of anti-heat shock protein 70 antibody and postoperative morbidity in patients with esophageal cancer. European Surgery.47(3) :117-122,2015
  • Yamanaka T et al. Umbilical hernia with cholelithiasis and hiatal hernia: a clinical entity similar to Saint’s triad. Surgical case reports.1(1) :65,2015
  • Miyazaki T et al. Phase I/II study of docetaxel, cisplatin, and 5-fluorouracil combination chemoradiotherapy in patients with advanced esophageal cancer. Cancer chemotherapy and pharmacology.75(3) :449-455,2015
  • Miyazaki T et al. Successful Tumor Navigation Technique During Intrathoracoscopic Esophagectomy: Laparoscopic Ultrasonography Using Endoscopically Placed Marking Clips. Journal of the American College of Surgeons.221(6) :e125-e128,2015
  • Miyazaki T et al. Phase II Study of Docetaxel, Nedaplatin, and 5-Fluorouracil combined chemotherapy for advanced esophageal cancer. Annals of surgical oncology.22(11) :3653-3658,2015
  • Sakai M et al. Usefulness of 18f-Fluorodeoxyglucose Positron Emission Tomography for Predicting the Pathological Response of Neoadjuvant Chemoradiotherapy for T4 Esophageal Squamous Cell Carcinoma.Hepato-gastroenterology.62(140) :898-901,2015
  • Nakajima M et al. Planned Esophagectomy after Neoadjuvant Hyperthermo-Chemoradiotherapy using Weekly Low-Dose Docetaxel and Hyperthermia for Advanced Esophageal Carcinomas...Hepato-gastroenterology.62(140) :887-891,2015
  • Yokobori T et al. Nuclear PROX1 is associated with hypoxia-inducible factor 1α expression and cancer progression in esophageal squamous cell carcinoma. Annals of surgical oncology.22(3) :1566-1573,2015
  • Sakai M et al. Single-Incision Laparoscopic Surgery for a Small-Intestinal Gastrointestinal Stromal Tumor: Report of a Case. International surgery.99(4) :463-466,2014
  • Sohda M et al. L-[3-18F]-α-Methyltyrosine Accumulation as a Definitive Chemoradiotherapy Response Predictor in Patients with Esophageal Cancer. Anticancer research.34(2) :909-913,2014
  • Sohda M et al. L-[3-18F]-α-Methyltyrosine Uptake by Lymph Node Metastasis Is a Predictor of Complete Response to CRT in Esophageal Cancer. Anticancer research.34(12) :7473-7477,2014
  • Sohda M et al. Use of pre-treatment 18F-FAMT PET to predict patient survival in squamous cell carcinoma of the esophagus treated by curative surgery. Anticancer research.34(7) :3623-3628,2014
  • Miyazaki T et al. Effectiveness of FDG-PET in screening of synchronous cancer of other organs in patients with esophageal cancer. Anticancer research.34(1) :283-287,2014
  • Miyazaki T et al. Phase I dose-escalation study of docetaxel, nedaplatin, and 5-fluorouracil combination chemotherapy in patients with advanced esophageal cancer. Cancer chemotherapy and pharmacology.71(4) :853-857,2013
  • Saito K et al. Laparoscopy-assisted resection of ileocecal intussusception caused by ileal pedunculated lipoma. International surgery.98(4) :330-333,2013
  • Inose T et al. Surgical treatment for nonspecific esophageal motility disorders. Surgery today.43(8) :877-882,2013
  • Sano A et al. Expression of receptor tyrosine kinases in esophageal . Oncology reports.29(6) :2119-2126,2013
  • Miyazaki T et al. Clinical significance of total colonoscopy for screening of colon lesions in patients with esophageal cancer. Anticancer research.33(11) :5113-5117,2013
  • Miyazaki T et al. Re-thoracotomy for intrathoracic complications after esophagectomy for esophageal cancer. Kyobu geka. The Japanese journal of thoracic surgery.66(8 Suppl) :762-766,2013
  • Miyazaki T et al. Management of Barrett’s esophageal carcinoma. Surgery today.43(4) :353-360,2013
  • Miyazaki T et al. Japanese Classification Esophageal Society Japanese Classification Esophageal Society, 2008.Surgery today.43(4) :353-360,2013
和文論文・著書
  • 酒井 真、斉藤秀幸、栗山健吾、吉田知典、熊倉裕二、原圭吾、宗田 真、桑野博行、調 憲:【胸部外科を支えるテクノロジーup to date】食道領域 高解像度食道内圧検査(HRM) を用いた食道運動評価法. 胸部外科 71(10):894-99,2018
  • 宗田 真、桑野博行:食道悪性腫瘍. 内科学第11版 905-909, 2017
  • 酒井 真、栗山健吾、吉田知典、熊倉裕二、宗田 真、宮崎達也、桑野博行:アカラシアに対する手術ステップごとに理解する. 標準術式アトラス. 臨床外科増刊号72(11) 23-27, 2017
  • 宮崎達也、宗田 真、酒井 真、茂木陽子、田中成岳、桑野博行:個々の患者の病態を把握し術前栄養療法を選択する. 栄養経営エキスパート2(4)22-25,2017
  • 宮崎達也、宗田 真、酒井 真、栗山健吾、本城裕章、熊倉裕二、吉田知典、桑野博行:術後トラブルシューティング―食道癌術後の合併症とその対処. 外科79(4)314-318, 2017
  • 宗田 真、桑野博行:食道癌手術における栄養評価と周術期管理. 胸部外科70(8)708-711, 2017
  • 宮崎達也、宗田 真、酒井 真、栗山健吾、本城裕章、熊倉裕二、吉田知典、桑野博行:切除可能食道癌に対する外科診療. 消化器・肝臓内科1(4)370-376, 2017
  • 増田典弘、宮崎達也、桑野博行:癌のステージング 食道癌. 診断と治療10(5)98-104, 2017
  • 宗田 真、桑野博行:食道癌-最新の治療戦略. 臨床と研究94(12)10-13, 2017
  • 宗田 真、桑野博行:胸腔鏡下食道癌手術における剥離層の選択. 臨床外科72(7)784-788, 2017
  • 増田典弘、宗田 真、宮崎達也、桑野博行:【急性腹症の外科手術-最新知見】 「特発性食道破裂」に対する外科手術ー 救命を可能にするパッチとドレナージのコツー. 手術 70(6):713-720, 2016
  • 宮崎達也、宗田 真、酒井 真、熊倉裕二、本城裕章、吉田知典、田中成岳、横堀武彦、福地 稔、桑野博行:特集 外科臨床研究のノウハウと重要研究の総まとめ Part2:押さえておきたい外科臨床研究の総まとめ 食道癌. 臨床外科 71(5): 548-553, 2016
  • 酒井 真、桑野博行:食道癌に対する経食道的内視鏡治療.胸部外科 69(8): 718-723,2016
  • 酒井 真、宗田 真、宮崎達也、桑野博行:特発性食道破裂.臨床外科 71(11): 215-219, 2016
  • 宗田 真、桑野博行:縦隔リンパ節郭清術のコツと要点.臨床外科 71(9): 1083-6, 2016
  • 横堀武彦、桑野博行:特集1.健康寿命を延ばすために がんを克服して健康寿命を延ばすために.成人病と生活習慣病 46(5): 545-549, 2016
  • 国立大学法人 群馬大学
  • 群馬大学医学部附属病院 臨床研修センター
  • National Clinical Database 外科系の専門医制度と連携した症例データベース

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