呼吸器外科【患者様へ】  

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研究

|　研究の背景

　呼吸器外科では、肺癌、転移性肺腫瘍、縦隔腫瘍などの悪性疾患に加え、良性腫瘍、感染性肺疾患、膿胸、気胸などの数多くの胸部疾患を取り扱っています。この中でも肺癌は頻度が一番多く、日本でも罹患数が年間12万人、死亡数が7万人をこえ全癌死の1位であり難治性疾患です。

　肺癌の治療で手術は中心的な役割を担っていますが、近年、根治性を担保しつつ、より低侵襲を目指した診療が行われるようになってきています。低侵襲手術の代表として、胸腔鏡下手術（胸腔鏡をもちいて小さい切開創のみで行う手術）と、呼吸機能温存のため区域という肺の解剖学的最小範囲で肺癌を切除する術式（区域切除術）を組み合わせた胸腔鏡下肺区域切除という手術が盛んに行われるようになってきました。しかし、この手術は肺葉切除術と比較し、詳細な肺解剖の理解と繊細な技術が要求される手術です。我々は、胸腔鏡下肺区域切除を10年以上前より精力的に行っており、多くの症例経験を有しています。また、安全・確実に行うための努力として、様々な臨床研究も行っています（「臨床研究」欄参照）。

　また、肺癌治療は、現在手術単独では制御が難しいことも多く、より有効な薬物療法の開発が期待されています。肺癌の薬物療法は、近年飛躍的に進歩・変遷し、2004年に分子標的薬が登場し、さらに2016年より免疫チェックポイント分子阻害薬が臨床応用され、症例を適切に選択することにより、これまで標準治療であった従来の抗癌剤よりも有効な治療法となっています。ただし、それらの効果は一部の症例に限られ、一時的で根治に至らない症例が依然として多いことから、一層の基礎研究を推進していく必要があります。

　現在、当教室では、呼吸器外科領域の疾患を対象に、基礎研究から臨床研究、そして臨床試験まで様々な分野の研究を行っています。

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|　主な研究テーマ

• 3DCT画像を用いた肺の局所解剖研究と完全鏡視下肺区域切除の新規術式の開発―安全・確実な術式を目指して―
• 転移性肺腫瘍の切除適応の確立
• 胸腺腫瘍の遺伝子変異/多型/発現形式に関する研究
• 肺神経内分泌腫瘍に関する新規治療の開発

＜単施設臨床試験＞

• 肺瘻（難治性気胸や術後肺瘻）に対する胸膜癒着療法におけるピシバニール（OK432）の有効性と安全性の検討
  （https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000035522）
• 臓器横断的な呼吸器・胸部疾患の発生、病態、予後に関する後ろ向き観察研究
  （https://ciru.dept.showa.gunma-u.ac.jp/guidance/storage-sample/list.html）

＜多施設共同研究＞

• 肺癌合同委員会 胸腺上皮性腫瘍の前方視的データベース研究（https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000035481）
• 臨床病期IA3期の肺野末梢充実型非小細胞肺癌に対する肺葉切除と区域切除のランダム化比較第Ⅲ相試験
• 病理病期 IA2-IIA 期EGFR 遺伝子変異陽性非小細胞肺癌における術後補助療法の実態を調査する多施設共同前向き観察研究
• EGFR 遺伝子変異陽性非小細胞肺癌完全切除例の前向き観察研究

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3DCT画像を用いた肺の局所解剖研究とそのデータをもとにした区域切除モデルおよび新規区域切除術の開発

　最近では、より早期の小型肺癌が見つけられるようになっており、ただ手術をするのではなく、それらの小型早期肺癌に対しては、低侵襲なアプローチ法で、根治性を担保しながら正常肺を残し、術後に息苦しくならない手術に努めることが重要です。当院では、「痛を少なく＋息苦しくならないように」真の意味での患者さんに配慮した手術の開発に力を注いでいます。具体的には痛みを少なくするアプローチ法とは胸腔鏡を用いた手術（体に穴をあけるだけの手術）であり、苦しくならないようにする術式というのは、肺を大きくは取らずに区域という肺の解剖学的最小範囲で肺癌を切除する区域切除のことです（図１）。しかし、この術式は、解剖学的知識と繊細な技術が必要とされ、通常の標準手術である肺葉切除に比べても難易度が高いですが、呼吸機能を維持できるメリットがあります。そこで我々は、個々の患者さんの体の構造（局所解剖）を、3DCT画像（図２）を用いて詳細に解析・研究し、このデータをもとに区域切除を行うための地図もしくは設計図にあたるモデルを作成しました。現在はこのモデルを日常診療に応用し精度の高い区域切除術を行っていることはもちろん、更なる肺の温存術式の開発にも勢力的に取り組んでいます。これらの研究結果は、近年の日本の肺区域切除の礎になるものとして高く評価され、我々のグループが作成した研究論文が2年連続（2017年・2018年度）で、日本胸部外科学会雑誌General thoracic cardiovascular surgery (GTCS)誌の年間優秀論文賞に選ばれました。

|　関連論文

1. Nagashima T, Shimizu K, Ohtaki Y, Obayashi K, Kakegawa S, Nakazawa S, Kamiyoshihara M, Igai H, Takeyoshi I: An analysis of variations in the bronchovascular pattern of the right upper lobe using three-dimensional CT angiography and bronchography. Gen Thorac Cardiovasc Surg 63: 354-60, 2015
2. Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Kamiyoshihara M, Igai H, Takeyoshi I, Mogi A, Kuwano H: Analysis of the variation pattern in right upper pulmonary veins and establishment of simplified vein models for anatomical segmentectomy. Gen Thorac Cardiovasc Surg 64: 604-11, 2016　2017年度 日本胸部外科学会General Thoracic and Cardiovascular Surgery (GTCS) 優秀論文賞
3. Shimizu K, Nagashima T, Yajima T, Ohtaki Y, Obayashi K, Nakazawa S, Kosaka T, Mogi A, Kuwano H: Thoracoscopic Medial-Basal Segment (S7) Segmentectomy. Ann Thorac Surg 104: e403-e406, 2017
4. Shimizu K, Mogi A, Yajima T, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Kosaka T, Kuwano H: Thoracoscopic Subsuperior Segment (S*) Segmentectomy. Ann Thorac Surg 104: e407-e410, 2017
5. Nagashima T, Shimizu K, Ohtaki Y, Obayashi K, Nakazawa S, Mogi A, Kuwano H: Analysis of variation in bronchovascular pattern of the right middle and lower lobes of the lung using three-dimensional CT angiography and bronchography. Gen Thorac Cardiovasc Surg 65: 343-9，2017 2018年度 日本胸部外科学会General Thoracic and Cardiovascular Surgery (GTCS) 優秀論文賞
6. Yajima T, Shimizu K, Mogi A, Kosaka T, Nakazawa S, Shirabe K: Thoracoscopic right middle lobe segmentectomy. Gen Thorac Cardiovasc Surg doi:10.1007/s11748-018-0964-4, 2018

　当グループでは肺癌を始め、胸部悪性疾患を対象とした基礎研究に取り組んでおります。特に基礎研究を基盤に、疾患の新たな診断法や治療法に発展しうる様なtranslational researchを目指します。具体的には以下に示すような、腫瘍モデルを用いた腫瘍免疫応答のメカニズム解明、肺癌の新規治療標的としてのStathmin familyの探求、及び肺癌における非定型ユビキチンの機能解析などに取り組んでおります。

• 腫瘍免疫応答における活性化CD8T細胞の疲弊化誘導のメカニズム解明
• Stathmin分子をターゲットにした肺癌治療法の開発
• 肺癌における非定型ユビキチンシグナルの機能解析

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腫瘍免疫応答における活性化CD8T細胞の疲弊化誘導のメカニズム解明

　抗原特異的CD8T細胞は腫瘍免疫応答で重要ですが、それらは疲弊化し十分に抗腫瘍効果を発揮できません。近年、PD-1/PD-L1を含めた免疫チェックポイント分子が疲弊化のメカニズムとして解明され、そのシグナルをブロックする癌免疫療法が肺癌において臨床応用されています。しかし、その効果は一部に限定され一時的で、更なる疲弊化誘導のメカニズム解明が必要です。近年、新規免疫チェックポイント分子としてLAG-3、TIM-3、TIGITなどが報告されていますが、その効果は十分でなく、いまだ未知の免疫チェックポイント分子が存在することが想定されます(図1)。

　これらを解明する上で問題となるのは、腫瘍免疫応答では十分な数の抗原特異的CD8T細胞が誘導されず、解析が困難なことがあげられます。我々は、これまで感染免疫で抗原特異的C8T細胞の産生、維持の分子機構解析を行い、いくつかの研究成果をあげてきました。現在、感染免疫で用いた系を応用し、腫瘍モデルで抗原特異的疲弊化CD8T細胞を通常の10～20倍誘導することを可能にしました。これらの系で、抗原特異的C8T細胞における疲弊化誘導の分子機構を解析すると共に新規免疫チェックポイントの探索を行っています。

　これらの研究成果は、免疫チェックポイント分子阻害薬を用いた癌免疫療法の分子機構がさらに解明されるだけでなく、新規癌免疫療法の開発につながる可能性があります。

|　関連論文

1. Yajima T et al. Fas/FasL signaling is critical for the survival of exhausted antigen-specific CD8+ T cells during tumor immune response. Mol Immunol. 2019 107:97-105. 
2. Yajima T et al. IL-15 regulates CD8+ T cell contraction during primary infection. J Immunol. 2006 176(1):507-15.
3. Yajima T et al. A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection. J Immunol. 2005 174(6):3590-7.
4. Yajima T et al. Overexpression of interleukin-15 in vivo enhances antitumor activity against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response. Int J Cancer. 2002 99(4):573-8.
5. Yajima T et al. Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure. J Immunol. 2002 168(3):1198-203.

|　関連研究費

2016年度-2018年度　基盤研究（Ｃ）腫瘍切除後のメモリーCD8T細胞誘導による新規癌免疫アジュバント療法の開発

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Stathmin分子をターゲットにした肺癌治療法の開発

　がん細胞にとっても微小管は細胞生存に重要であり、微小管を不安定化するStathmin 1 (STMN1)という癌特異的タンパクはがんマーカー、治療標的分子として注目されていいます。我々は、肺癌とSTMN1との関連に着目し研究を行い、これまでに肺癌においてSTMN1が過剰発現し、癌の進行、予後不良と関連すること（図１）、微小管標的タキサン系抗がん剤の耐性を誘導することを報告してきました[1,2]。また、その研究過程において、特に高悪性度肺神経内分泌腫瘍 [HGNET：大細胞神経内分泌癌 (LCNEC) +小細胞癌 (SCLC)] におけるSTMN1の発現が全癌腫の中で最も高く、さらにその発現はHGNET全症例、かつ腫瘍全体で均一に高いレベルであることを見出しています[3]。また、最近ではSTMN1のfamilyであるSTMN2, 3, 4もHGNETと関連があることも見出しました。そこで我々は、HGNETとSTMN familyとの関連をさらに詳しく解析し、STMN familyを特異的に抑制する治療を、高悪性度かつ難治性のHGNETに対する新たな治療戦略とすることを目的に日々研究を行っています。

|　関連論文

1. Shimizu K, Ohtaki Y, Altan B, Yokobori T, Nagashima T, Arai M, Mogi A, Kuwano H: Prognostic impact of stathmin 1 expression in patients with lung adenocarcinoma. J Thorac Cardiovasc Surg. 154:1406-1417, 2017.
2. Bao P, Yokobori T, Altan B, Iijima M, Azuma Y, Onozato R, Yajima T, Watanabe A, Mogi A, Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Bai T, Kawabata-Iwakawa R, Asao T, Kaira K, Nishiyama M, Kuwano H: High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma. Ann Surg Oncol. 24: 4017-24,2017.
3. Shimizu K, Goto Y, Kawabata-Iwakawa R, Ohtaki Y, Nakazawa S, Yokobori T, Obayashi K, Kawatani N, Yajima T, Kaira K, Mogi A, Hirato J, Nishiyama M, Shirabe K: Stathmin-1 is a useful diagnostic marker for high-grade lung neuroendocrine tumors. Ann Thorac Surg. In press, 2019.

|　関連研究費

第50回高松宮癌研究基金研究助成金：微小管ダイナミクス制御タンパクStathmin1を標的とした難治性小細胞肺癌に対する新規治療ツールの開発

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肺癌における非定型ユビキチンシグナルの機能解析

　ユビキチンは76個のアミノ酸からなるタンパク質であり、タンパクにユビキチンを付加することを「ユビキチン化（ユビキチン修飾）」と言います。ユビキチン同士の結合様式の違いによって8種類のユビキチン鎖が存在し、それぞれ機能が異なります。中でもK48ユビキチン修飾は標的タンパクをプロテアソーム分解への誘導が良く知られていて、例えばMDM2というユビキチン修飾を行う酵素（ユビキチンリガーゼ）が癌抑制タンパク質であるp53にK48ユビキチン鎖を付加すると、p53が分解され、癌の発症に関与します。

　現状ではK48以外の非定型ユビキチン鎖（K6、K11、K27、K29、K33、K63、M1）の機能は未解明な部分が多く、当センターでは2016年にM1ユビキチンシグナルを介したNF-KBやアポトーシス制御の機能解析、及び、筋萎縮性側索硬化症との関連を報告しました [1]。現在、呼吸器外科グループではこの研究を踏まえ、肺癌におけるM1ユビキチン鎖とその合成酵素（LUBAC）の機能解析を進めています（図1）。

　特に肺癌の発生、進展、転移におけるM1ユビキチンの機能を明らかにすることで、肺癌の診断や新規治療開発への架け橋となる事が期待されます。

|　関連論文

1. Nakazawa S, Oikawa D, Ishii R, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 7:12547, 2016.
2. Nakazawa S, Mamiya R, Kawabata-Iwakawa R et al. Identification and molecular analysis of RNF31 Q622H germline polymorphism. Oncol Lett 2022;24:394.
3. Hoshino K, Nakazawa S, Yokobori T et al. RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation. Sci Rep 2024;14:346.

|　関連研究費

2017-2018年度　科学研究費・若手(B)、武田科学振興財団・医学系研究助成

科学研究費　2017-2018年度　若手研究（B）

科学研究費　2019-2020年度　若手研究　

武田科学振興財団　2018年度　医学系研究助成（がん領域・基礎

業績

|　受賞歴

中澤世識
・Early Career Education Award (IASLC 2023 World Conference on Lung Cancer).

河谷菜津子　
・第73回手術手技研究会「ビデオ賞」

矢澤友弘
・Reviewer of the Month in Annals of Translational Medicine (2021)
・北関東医学会奨励賞 (2023)
・日本胸部外科学会JATSフェローシップ (2024)

吉川良平　
・第125回日本外科学会定期学術集会 Young Investigator’s Award

|　科研費・研究助成金

中澤世識
・2022年度　第一三共生命科学研究振興財団　海外留学奨学研究助成
・横山臨床薬理研究助成　令和2年度　一般研究助成
・SymBio Pharmaceuticals　2021-2022

河谷菜津子
 ・2020年度　科学研究費補助金受給（基盤研究C)

矢澤友弘
・大鵬薬品　奨学寄付金(2023年)

吉川良平
 ・がん研究振興財団　令和6年度TR事業研究奨励助成金

|　英文論文・著書

2025年

Nakazawa S, Pecci F, Ricciuti B, Gottlieb FH, Facchinetti F, Harada G, et al. Activating Mutations in the MET Kinase Domain Co-Occur With Other Driver Oncogenes and Mediate Resistance to Targeted Therapy in NSCLC. J Thorac Oncol 2025 doi 10.1016/j.jtho.2025.03.045.

Nakazawa S, Pecci F, Odintsov I, Gazgalis D, Gottlieb FH, Ricciuti B, et al. Antitumor activity of vebreltinib and characterization of clinicogenomic features in solid tumors with MET rearrangements. Cancer Discov 2025 doi 10.1158/2159-8290.CD-24-1726.

Yazawa T, Nagashima T, Ohtaki Y, Kawatani N, Yoshikawa R, Narusawa E, et al. Left inferior lingual and ventrobasal (S5 + S8) video-assisted thoracoscopic surgery segmentectomy using intersegmental tunneling for primary lung cancer. JTCVS Tech 2025;29:173-5 doi 10.1016/j.xjtc.2024.11.006.

Tateno Y, Yazawa T, Nagashima T, Ohtaki Y, Kawatani N, Yoshikawa R, et al. Thoracoscopic right apical segmentectomy in a patient with tracheal bronchus: a case report and review of literature. Int Cancer Conf J 2025;14(2):119-23 doi 10.1007/s13691-025-00746-1.

2024年

Pecci F, Nakazawa S, Ricciuti B, Harada G, Lee JK, Alessi JV, et al. Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors. Cancer Discov 2024;14(8):1440-56 doi 10.1158/2159-8290.CD-23-1217.

Ohtaki Y, Nagashima T, Okano N, Kubo N, Ohtaka T, Sunaga N, et al. Prognosis of non-small cell lung cancer with postoperative regional lymph node recurrence. Thorac Cancer 2024;15(11):859-66 doi 10.1111/1759-7714.15265.

Hoshino K, Nakazawa S, Yokobori T, Hagiwara K, Ishii N, Tsukagoshi M, et al. RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation. Sci Rep 2024;14(1):346 doi 10.1038/s41598-023-50594-3.

2023年

Nakazawa S, Nagashima T, Kawatani N, Gedeon PC, DeSimone AK, Igai H, et al. Anatomy of the lung revisited by 3D-CT imaging. Video Assist Thorac Surg 2023;8 doi 10.21037/vats-23-21.

Nakazawa S, Shimizu K, Yazawa T, Kawatani N, Obayashi K, Ohtaki Y, et al. Clinicopathological features and surgical outcomes of lobectomy combined with segmentectomy: a cohort study. J Thorac Dis 2023;15(3):1075-85 doi 10.21037/jtd-22-696.

Saito Y, Yazawa T, Nagashima T, Ohtaki Y, Kawatani N, Narusawa E, et al. Autoimmune alopecia areata due to thymoma without myasthenia gravis: a case report. Surg Case Rep 2023;9(1):68 doi 10.1186/s40792-023-01655-2.

Yazawa T, Igai H, Kamiyoshihara M, Shirabe K. Right basal bronchial fistula due to amebic infection: a case report. BMC Pulm Med 2023;23(1):117 doi 10.1186/s12890-023-02412-9.

Yazawa T, Igai H, Nagashima T, Shirabe K. How to manage bleeding and air leaks in thoracic surgery. J Thorac Dis 2023;15(9):4564-6 doi 10.21037/jtd-23-1161.

Kawatani N, Yajima T, Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, et al. Risk factors for late-onset pulmonary fistula after pulmonary segmentectomy. J Thorac Dis 2023;15(3):1009-17 doi 10.21037/jtd-22-1212.

2022年

Nakazawa S, Yajima T, Numajiri K, Kawatani N, Aoki F, Shirabe K. A "Catlike Cry" as a Symptom of Congenital Tracheoesophageal Fistula. Chest 2022;161(5):e255-e7 doi 10.1016/j.chest.2021.11.037.

Nakazawa S, Kawatani N, Obayashi K, Ohtaki Y, Ito T, Yajima T, et al. Clinical and anatomical features of the lateral costal artery and vein. Sci Rep 2022;12(1):10589 doi 10.1038/s41598-022-14318-3.

Ohtaki Y, Yajima T, Nagashima T, Nakazawa S, Kawatani N, Obayashi K, et al. Complex vs. simple segmentectomy: comparing surgical outcomes in the left upper division. Gen Thorac Cardiovasc Surg 2022;70(11):962-70 doi 10.1007/s11748-022-01816-4.

Nakazawa S, Mamiya R, Kawabata-Iwakawa R, Oikawa D, Kaira K, Tokunaga F, et al. Identification and molecular analysis of RNF31 Q622H germline polymorphism. Oncol Lett 2022;24(5):394 doi 10.3892/ol.2022.13514.

Ohtaki Y, Kawabata-Iwakawa R, Nobusawa S, Goto Y, Shimizu K, Yajima T, et al. Molecular and expressional characterization of tumor heterogeneity in pulmonary carcinosarcoma. Mol Carcinog 2022;61(10):924-32 doi 10.1002/mc.23448.

Gombodorj N, Azuma Y, Yokobori T, Erkhem-Ochir B, Kosaka T, Ohtaki Y, et al. RAB11A Expression Is Associated With Cancer Aggressiveness Through Regulation of FGFR-Signaling in Lung Squamous Cell Carcinoma. Ann Surg Oncol 2022;29(11):7149-62 doi 10.1245/s10434-022-11833-5.

Ohtaki Y, Yajima T, Obayashi K, Nakazawa S, Ikota H, Shirabe K. Video-assisted thoracoscopic segmentectomy with combined chest wall resection: A case report. J Cardiothorac Surg 2022;17(1):265 doi 10.1186/s13019-022-01996-3.

Nakazawa S, Shimizu K, Kawatani N, Obayashi K, Ohtaki Y, Kosaka T, et al. Surgical outcomes after multiple segmentectomy: a cohort study. J Thorac Dis 2022;14(1):113-22 doi 10.21037/jtd-21-1545.

Nakazawa S, Yajima T, Numajiri K, Kawatani N, Aoki F, Shirabe K. A "Catlike Cry" as a Symptom of Congenital Tracheoesophageal Fistula. Chest 2022;161(5):e255-e7 doi 10.1016/j.chest.2021.11.037.

2021年

Ohtaki Y, Kaira K, Yajima T, Erkhem-Ochir B, Kawashima O, Kamiyoshihara M, et al. Comprehensive expressional analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung. Thorac Cancer 2021;12(20):2666-79 doi 10.1111/1759-7714.14102.

Nakazawa S, Yajima T, Shirabe K. Congenital Tracheoesophageal Fistula in an Adult. Am J Respir Crit Care Med 2021;203(7):e27-e8 doi 10.1164/rccm.202003-0689IM.

Nakazawa S, Atsumi J, Yajima T, Shirabe K. Pneumothorax in Long-term Ventilator Users With Neuromuscular or Neurodegenerative Disease. Chest 2021;160(3):e323-e4 doi 10.1016/j.chest.2021.04.073.

Nakazawa S, Hanawa R, Nagashima T, Shimizu K, Yajima T, Shirabe K. Segmentectomy Guided by 3-Dimensional Images Reconstructed From Nonenhanced Computed Tomographic Data. Ann Thorac Surg 2021;111(4):e301-e4 doi 10.1016/j.athoracsur.2020.07.098.

Yoshikawa R, Matsuura N, Igai H, Yazawa T, Ohsawa F, Kamiyoshihara M. Uniportal approach as an alternative to the three-portal approach to video-assisted thoracic surgery for primary spontaneous pneumothorax. J Thorac Dis 2021;13(2):927-34 doi 10.21037/jtd-20-2928.

Yazawa T, Igai H, Numajiri K, Ohsawa F, Matsuura N, Kamiyoshihara M. Comparison of stapler and electrocautery for division of the intersegmental plane in lung segmentectomy. J Thorac Dis 2021;13(11):6331-42 doi 10.21037/jtd-21-1397.

Nakazawa S, Yajima T, Numajiri K, Kawatani N, Obayashi K, Ohtaki Y, et al. Superior Lingular S. Ann Thorac Surg 2022;113(2):e141-e4 doi 10.1016/j.athoracsur.2021.04.050.

2020年以前

Iijima M, Yokobori T, Mogi A, Shimizu K, Yajima T, Kosaka T, Ohti Y, ak Obayashi K, Nakazawa S, Gombodorj N, Tsukagoshi M, Shirabe K, Kuwano H: Genetic and immunohistochemical studies investigating the histogenesis of neuroendocrine and carcinomatous components of combined neuroendocrine carcinoma. Ann Surg Oncol (In press 2019)

Kaira K, Kamiyoshihara M, Kawashima O, Endoh H, Imaizumi K, Sugano M, Tanaka S, Fujita A, Kogure Y, Shimizu A, Oyama T, Asao T, Shimizu K, Mogi A: Prognostic Impact of β2 Adrenergic Receptor Expression in Surgically Resected Pulmonary Pleomorphic Carcinoma. Anticancer Res. 39:395-403, 2019

Kaira K, Nasuse I, Shimizu K, Asao T: Interstitial lung disease secondary to after interstitial injury induced by crizotinib. J Cancer Res Ther. DOI: 10.4103/jcrt.JCRT_985_15, 2019

Kosaka T, Shimizu K, Nakazawa S, Obayashi K, Ohtaki Y, Kawatani N, Ibe T, Yajima T, Mogi A, Shirabe K: Will minimally invasive sleeve resection become the future trend for treatment of advanced lung cancer? (Editorial) J Thorac Dis (In press 2019)

Ohtaki Y, Shimizu K, Kawabata-Iwakawa R, Gombodorj N, Altan B, Rokudai S, Yamane A,　Kaira K, Yokobori T, Nagashima T, Obayashi K, Nakazawa S, Iijima M, Kosaka T, Yajima T, Mogi A, Kuwano H, Shirabe K, Nishiyama M: Carbonic anhydrase 9 expression is associated with poor prognosis, tumor proliferation, and radiosensitivity of thymic carcinomas. Oncotarget 10: 1306-19, 2019

Ohtaki Y, Shimizu K, Saitoh J, Kamiyoshihara M, Mogi A, Nakazawa S, Ohno T, Shirabe S: Is salvage surgery for patients with lung cancer after carbon ion radiotherapy easy or difficult?   Interact Cardiovasc Thorac Surg doi: 10.1093/icvts/ivy350. 2019

Shimizu K, Ohtaki Y, Okumura T, Boku N, Horio H, Takenoyama M, Yamashita M, Hyodo I, Mori K, Kondo H: Outcomes and prognostic factors after pulmonary metastasectomy in patients with colorectal cancer with previously resected hepatic metastases. J Thorac Cardiovasc Surg. doi: 10.1016/j.jtcvs.2019

Shimizu K, Goto Y, Kawabata-Iwakawa R, Ohtaki Y, Nakazawa S, Yokobori T, Obayashi K, Kawatani N, Yajima T, Kaira K, Mogi A, Hirato J, Nishiyama M, Shirabe K: Stathmin-1 is a useful diagnostic marker for high-grade lung neuroendocrine tumors. Ann Thorac Surg (In press 2019)

Yajima T, Hoshino K, Muranushi R, Mogi A, Onozato R, Yamaki E, Kosaka T, Tanaka S, Shirabe K, Yoshikai Y, Kuwano H. Fas/FasL signaling is critical for the survival of exhausted antigen-specific CD8+ T cells during tumor immune response. Mol Immunol. 107:97-105, 2019

Yajima T, Shimizu K, Mogi A, Kosaka T, Nakazawa S, Shirabe K. Thoracoscopic right middle lobe segmentectomy. Gen Thorac Cardiovasc Surg 67:344-7, 2019

Yajima T, Shimizu K, Mogi A, Kosaka T, Nakazawa S, and Shirabe K. Medial-basal Segment (S7)-sparing Right Basal Segmentectomy.  Gen Thorac Cardiovasc Surg (In press 2019) 

Yajima T, Shimizu K, Mogi A, Ibe T, Ohtaki Y, Obayashi K, Nakazawa S, Kawatani N, Shirabe K: Pulmonary Artery Compression Facilitates Intersegmental Border Visualization.        Ann Thorac Surg (In press 2019)

Bao H, Bai T, Takata K, Yokobori T, Ohnaga T, Hisada T, Maeno T, Bao P, Yoshida T, Kumakura Y, Honjo H, Sakai M, Sohda M, Fukuchi M, Altan B, Handa T, Ide M, Miyazaki T, Ogata K, Oyama T, Shimizu K, Mogi A, Asao T, Shirabe K, Kuwano H, Kaira K: High expression of carcinoembryonic antigen and telomerase reverse transcriptase in circulating tumor cells is associated with poor clinical response to the immune checkpoint inhibitor nivolumab. Oncol Lett 15: 3061-7, 201

Igai H, Kamiyoshihara M, Yoshikawa R, Ohsawa F, Tomohiro Y, Shimizu K: Management of intraoperative bleeding during thoracoscopic pulmonary resection in Japan. J Vis Surg 4: 225-9, 2018

Kaira K, Shimizu K, Kitahara S, Yajima T, Atsumi J, Kosaka T, Ohtaki Y, Higuchi T, Oyama T, Asao T, Mogi A: 2-Deoxy-2-[fluorine-18] fluoro-d-glucose uptake on positron emission tomography is associated with programmed death ligand-1 expression in patients with pulmonary adenocarcinoma. Eur J Cancer 101: 181-190, 2018

Kaira K, Kawashima O, Endoh H, Imaizumi K, Goto Y, Kamiyoshihara M, Sugano M, Yamamoto R, Osaki T, Tanaka S, Fujita A, Imai H, Kogure Y, Seki Y, Shimizu K, Mogi A, Shitara Y, Oyama T, Kanai Y, Asao T: Expression of amino acid transporter (LAT1 and 4F2hc) in pulmonary pleomorphic carcinoma. Hum Pathol S0046-8177(18): 30384-8, 2018

Kaira K, Higuchi T, Naruse I, Arisaka I, Tokue A, Altan B, Suda S, Mogi A, Shimizu K, Sunaga N, Hisada T, Kitano S, Obinata H, Yokobori T, Mori1 K, Nishiyama M, Tsushima T, Asao T: Metabolic activity by 18F-FDG-PET/CT is predictive for early response after nivolumab in previously treated NSCLC. Eur J Nucl Med 45:56-66, 2018

Kasahara N, Kaira K, Bao P, Higuchi T, Arisaka Y, Erkhem-Ochir B, Sunaga N, Ohtaki Y, Yajima T, Kosaka T, Oyama T, Yokobori T, Asao T, Nishiyama M, Tsushima Y, Kuwano H, Shimizu K, Mogi A: Correlation of tumor-related immunity with 18F-FDG-PET in pulmonary squamous-cell carcinoma. Lung Cancer 119:71-7, 2018

Kumasaka S, Nakajima T, Arisaka Y, Tokue A, Achmad A, Fukushima Y, Shimizu K, Kaira K, Tetsuya H, Tsushima Y: Prognostic Value of Metabolic Tumor Volume of Pretreatment 18F-FAMT PET/CT in Non-Small Cell Lung Cancer. BMC Med Imaging 18: 46, 2018

Nakazawa S, Shimizu K, Mogi A, Kuwano H: VATS segmentectomy: past, present, and future.   Gen Thorac Cardiovasc Surg 66: 81-90, 2018

Nakazawa S, Shimizu K, Kawatani N, Obayashi K, Kosaka T, Ibe T, Yajima T, Mogi T, Shirabe K: Management of intraoperative bleeding during video-assisted thoracoscopic surgery.        J Vis Surg 4: 245 2018

Nakazawa S, Shimizu K, Mogi A, Kuwano H: Low diffusing capacity, emphysema, or pulmonary fibrosis: who is truly pulling the lung cancer strings? (Editorial) J Thorac Dis 10: 600-2, 2018

Niho S, Ikeda N, Michimae H, Suzuki K, Sakai H, Kaburagi T, Yoshiya K, Minato K, Kato T, Okamoto H, Seto T, Hosomi Y, Shimizu K, Saito H, Tsuchida M, Kunitoh H, Tsuboi M, Takeuchi M, Watanabe K: Overall survival results of the feasibility study of adjuvant chemotherapy with docetaxel plus cisplatin followed by long-term single-agent administration of S-1 in patients with completely resected non-small cell lung cancer: Thoracic Oncology Research Group (TORG) 0809. Am J Clin Oncol doi: 10.1097/COC.0000000000000438, 2018 [Epub ahead of print]

Obayashi K, Shimizu K, Nakazawa S, Nagashima T, Yajima T, Kosaka K, Atsumi J, Kawatani N, Yazawa T, Kaira K, Mogi A, Kuwano H: The impact of histology and ground-glass opacity component on volume doubling time in primary lung cancer. J Thorac Dis 10: 5428-5434, 2018

Obayashi K, Shimizu K, Nakazawa S, Ohtaki Y, Kawatani N, Ibe T, Yajima T, Mogi A, Kuwano H: A Leopard Can't Change Its Spots. Can A T790M Mutation-positive Cancer Change Its Spots After EGFR-TKI therapy. (Editorial) J Thorac Dis doi: 10.21037/jtd.2018.10.53, 2018

Ohtaki Y, Shimizu K, Nagashima T, Nakazawa S, Obayashi K, Azuma Y, Iijima M, Kosaka T, Yajima T, Ogawa H, Tsutsumi S, Arai M, Mogi A, Kuwano H: Clinical and radiological discrimination of solitary pulmonary lesions in colorectal cancer patients. World J Surg 42: 1161-70, 2018

Ohtaki Y, Kaira K, Atsumi J, Nagashima T, Kawashima O, Ibe T, Kamiyoshihara M, Onozato R, Fujita A, Yazawa T, Sugano M, Iijima M, Nakazawa S, Obayashi K, Kosaka T, Yajima T, Kuwano H, Shirabe K, Mogi A, Shimizu K: Prognostic significance of PD-L1 expression and tumor infiltrating lymphocytes in large cell neuroendocrine carcinoma of lung. Am J Transl Res 10:3243-53, 2018

Shimizu K, Nakazawa S, Mogi A, Kuwano H: Segmentectomy of the left superior segment (S6)    4 years after segmentectomy of the left dorsobasal segment (S10). J Thorac Cardiovasc Surg 155: 1302-4, 2018

Shimizu K, Ohtaki Y, Nakazawa S, Obayashi K, Nagashima T, Yajima T, Mogi A, Shirabe K: Minimally invasive open-window thoracostomy using wound edge protectors. Ann Thorac Surg     doi: 10.1016/j.athoracsur. 2018

Yajima T, Mogi A, Shimizu K, Kosaka T, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Iijima M, Yoshida Y, Hirato J, Kuwano H: Ectopic thymoma in the paratracheal region of the middle mediastinum: a rare case report and literature review. BMC Res Notes 25; 11: 256, 2018

Bao P, Yokobori T, Altan B, Iijima M, Azuma Y, Onozato R, Yajima T, Watanabe A, Mogi A, Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Bai T, Kawabata-Iwakawa R, Asao T, Kaira K, Nishiyama M, Kuwano H: High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma. Ann Surg Oncol 24: 4017-24, 2017

Igai H, Kamiyoshihara M, Kawatani N, Shimizu K: Thoracoscopic right upper lobectomy after an initial anatomic pulmonary resection of the lower lobe. Multimed Man Cardiothorac Surg doi: 10.1510, 2017

Imai H, Kuwako T, Kaira K, Masuda T, Miura Y, Seki K, Sakurai R, Utsugi M, Shimizu K, Sunaga N, Tomizawa Y, Ishihara S, Ishizuka T, Mogi A, Hisada T, Minato K, Takise A, Saito R, Yamada M: Evaluation of gefitinib efficacy according to body mass index, body surface area, and body weight in patients with EGFR-mutated advanced non-small cell lung cancer. Cancer Chemother Pharmacol 79: 497-505, 2017

Kamiyoshihara M, Ibe T, Kawatani N, Ohsawa F, Yoshikawa R, Shimizu K. Three-Dimensional Computed Tomography Helps Identify Muscles for Use in an Empyema Cavity. Ann Thorac Surg 103: e457, 2017

Kamiyoshihara M, Ibe T, Igai H, Kawatani N, Ohsawa F, Yoshikawa R, Shimizu K: Paraspinous muscle flap for the treatment of an empyema cavity: three case reports. Gen Thorac Cardiovasc Surg 65: 297-301, 2017

Nagashima T, Shimizu K, Ohtaki Y, Obayashi K, Nakazawa S, Mogi A, Kuwano H: Analysis of variation in bronchovascular pattern of the right middle and lower lobes of the lung using three-dimensional CT angiography and bronchography. Gen Thorac Cardiovasc Surg 65: 343-9，2017（2018年度 General Thoracic and Cardiovascular Surgery (GTCS) 優秀論文賞）

Ohtaki Y, Shimizu K, Aokage K, Nakao M, Yoshida J, Kamiyoshihara M, Sugano M, Takahashi Y, Nakazawa S, Nagashima T, Obayashi K, Hishida T, Tsuboi M, Mori S, Mun M, Okumura S, Igai H, Matsutani N, Mogi A, Kuwano H: Histology is a Prognostic Indicator After Pulmonary Metastasectomy from Renal Cell Carcinoma. World J Surg 41: 771-9, 2017

Otaka Y, Rokudai S, Kaira K, Fujieda M, Horikoshi I, Iwakawa-Kawabata R, Yoshiyama S, Yokobori T, Ohtaki Y, Shimizu K, Oyama T, Tamura J, Prives C, Nishiyama M: STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma. Clin Cancer Res 23: 3442-52, 2017

Shimizu K, Ohtaki Y, Altan B, Yokobori T, Nagashima T, Arai M, Mogi A, Kuwano H: Prognostic impact of stathmin 1 expression in patients with lung adenocarcinoma. J Thorac Cardiovasc Surg 154:1406-1417, 2017

Takase Y, Usui K, Shimizu K, Kimura Y, Ichihara T, Ohkawa T, Atsumi J, Enokida Y, Nakazawa S, Obayashi K, Ohtaki Y, Nagashima T, Mitani Y, Takeyoshi I: Highly sensitive detection of a HER2 12-base pair duplicated insertion mutation in lung cancer using the Eprobe-PCR method. PLoS One 12: e0171225, 2017

Seow WJ, Matsuo K, Hsiung CA, Shiraishi K, Song M, Kim HN, Wong MP, Hong YC, Hosgood HD 3rd, Wang Z, Chang IS, Wang JC, Chatterjee N, Tucker M, Wei H, Mitsudomi T, Zheng W, Kim JH, Zhou B, Caporaso NE, Albanes D, Shin MH, Chung LP, An SJ, Wang P, Zheng H, Yatabe Y, Zhang XC, Kim YT, Shu XO, Kim YC, Bassig BA, Chang J, Ho JC, Ji BT, Kubo M, Daigo Y, Ito H, Momozawa Y, Ashikawa K, Kamatani Y, Honda T, Sakamoto H, Kunitoh H, Tsuta K, Watanabe SI, Nokihara H, Miyagi Y, Nakayama H, Matsumoto S, Tsuboi M, Goto K, Yin Z, Shi J, Takahashi A, Goto A, Minamiya Y, Shimizu K, Tanaka K, Wu T, Wei F, Wong JY, Matsuda F, Su J, Kim YH, Oh IJ, Song F, Lee VH, Su WC, Chen YM, Chang GC, Chen KY, Huang MS, Yang PC, Lin HC, Xiang YB, Seow A, Park JY, Kweon SS, Chen CJ, Li H, Gao YT, Wu C, Qian B, Lu D, Liu J, Jeon HS, Hsiao CF, Sung JS, Tsai YH, Jung YJ, Guo H, Hu Z, Wang WC, Chung CC, Lawrence C, Burdett L, Yeager M, Jacobs KB, Hutchinson A, Berndt SI, He X, Wu W, Wang J, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Hu L, Chen CH, Yang TY, Xu J, Guan P, Tan W, Wang CL, Sihoe AD, Chen Y, Choi YY, Hung JY, Kim JS, Yoon HI, Cai Q, Lin CC, Park IK, Xu P, Dong J, Kim C, He Q, Perng RP, Chen CY, Vermeulen R, Wu J, Lim WY, Chen KC, Chan JK, Chu M, Li YJ, Li J, Chen H, Yu CJ, Jin L, Lo YL, Chen YH, Fraumeni JF Jr, Liu J, Yamaji T, Yang Y, Hicks B, Wyatt K, Li SA, Dai J, Ma H, Jin G, Song B, Wang Z, Cheng S, Li X, Ren Y, Cui P, Iwasaki M, Shimazu T, Tsugane S, Zhu J, Jiang G, Fei K, Wu G, Chien LH, Chen HL, Su YC, Tsai FY, Chen YS, Yu J, Stevens VL, Laird-Offringa IA, Marconett CN, Lin D, Chen K, Wu YL, Landi MT, Shen H, Rothman N, Kohno T, Chanock SJ, Lan Q: Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet 26: 454-65, 2017

Shimizu K, Nakazawa S, Nagashima T, Kuwano H, Mogi A: 3D-CT anatomy for VATS segmentectomy. J Vis Surg 3: 88, 2017

Shimizu K, Nagashima T, Ohtaki Y, Takahashi T, Mogi A, Kuwano H: Pulmonary artery reconstruction with a tailor-made bovine pericardial conduit following sleeve resection of a long segmental pulmonary artery for the treatment of lung cancer: technical details of the dog-ear method for adjusting diameter during vascular anastomosis. Gen Thorac Cardiovasc Surg 65: 304-7, 2017

Shimizu K, Nagashima T, Yajima T, Ohtaki Y, Obayashi K, Nakazawa S, Kosaka T, Mogi A, Kuwano H: Thoracoscopic Medial-Basal Segment (S7) Segmentectomy. Ann Thorac Surg 104: e403-e406, 2017

Shimizu K, Mogi A, Yajima T, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Kosaka T, Kuwano H: Thoracoscopic Subsuperior Segment (S*) Segmentectomy. Ann Thorac Surg 104: e407-e410, 2017

Atsumi J, Shimizu K, Kaira K, Nagashima T, Ohtaki Y, Obayashi K, Kakegawa S, Kawashima O, Kamiyoshihara M, Sugano M, Takeyoshi I: The impact of a Bim deletion polymorphism on the survival of patients with completely resected non-small cell lung cancer. J Glob Oncol 2: 　15-25, 2016

Enokida Y, Shimizu K, Atsumi J, Kakegawa S, Takase Y, Kaira K, Yashima H, Araki T, Nakazawa S, Ohtaki Y, Nagashima T, Alexander L, Usui K, Ishikawa T, Hayashizaki Y, Takeyoshi I: Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma. Cancer Med 5: 1791-801, 2016

Igai H, Kamiyoshihara M, Yoshikawa R, Osawa F, Kawatani N, Ibe T, Shimizu K: The efficacy of thoracoscopic fissureless lobectomy in patients with dense fissures. J Thorac Dis 8: 3691-6, 2016

Igai H, Kamiyoshihara M, Ibe T, Kawatani N, Shimizu K: Surgical treatment for elderly patients with secondary spontaneous pneumothorax. Gen Thorac Cardiovasc Surg 64: 267-72, 2016

Kamiyoshihara M, Ibe T, Kawatani N, Ohsawa F, Yoshikawa R, Shimizu K: A convenient method for identifying a small pulmonary nodule using a dyed swab and geometric mapping. J Thorac Dis 8: 2556-61, 2016

Koga Y, Satoh T, Kaira K, Koka M, Hisada T, Hirato J, Altan B, Yatomi M, Ono A, Kamide Y, Shimizu Y, Aoki-Saito H, Tsurumaki H, Shimizu K, Mogi A, Ishizuka T, Yamada M, Dobashi K: Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study. Environ Health Prev Med 21: 492-500, 2016

Nakazawa S, Shimizu K, Nagashima T, Mogi A, Kuwano H: Quality of life after video-assisted surgery for lung cancer. (Correspondence) Lancet Oncol 17: e318, 2016

Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 7: 12547, 2016

Ohtaki Y, Shimizu K, Kaira K, Nagashima T, Obayashi K, Nakazawa S, Kakegawa S, Igai H, Kamiyoshihara M, Nishiyama M, Takeyoshi I: Risk factors associated with recurrence of surgically resected node-positive non-small cell lung cancer. Surg Today 46: 1196-208, 2016

Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Kamiyoshihara M, Igai H, Takeyoshi I, Mogi A, Kuwano H: Analysis of the variation pattern in right upper pulmonary veins and establishment of simplified vein models for anatomical segmentectomy. Gen Thorac Cardiovasc Surg 64: 604-11, 2016（2017年度 General Thoracic and Cardiovascular Surgery (GTCS) 優秀論文賞）

Shimizu K, Ohtaki Y, Nakazawa S, Mogi A, Kuwano H: Neither the maximum tumor size nor solid component size is prognostic in part-solid lung cancer: to be ground-glass opacity or not to be, is that really the question? J Thorac Dis 8: 2334-6, 2016

Shimizu A, Kaira K, Mori K, Kato M, Shimizu K, Yasuda M, Takahashi A, Oyama T, Asao T, Ishikawa O: Prognostic significance of β2-adrenergic receptor expression in malignant melanoma. Tumour Biol 37: 5971-8, 2016

Shiraishi K, Okada Y, Takahashi A, Kamatani Y, Momozawa Y, Ashikawa K, Kunitoh H, Matsumoto S, Takano A, Shimizu K, Goto A, Tsuta K, Watanabe S, Ohe Y, Watanabe Y, Goto Y, Nokihara H, Furuta K, Yoshida A, Goto K, Hishida T, Tsuboi M, Tsuchihara K, Miyagi Y, Nakayama H, Yokose T, Tanaka K, Nagashima T, Ohtaki Y, Maeda D, Imai K, Minamiya Y, Sakamoto H, Saito A, Shimada Y, Sunami K, Saito M, Inazawa J, Nakamura Y, Yoshida T, Yokota J, Matsuda F, Matsuo K, Daigo Y, Kubo M, Kohno T: Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. Nat Commun 7: 12451, 2016

Tanaka K, Shimizu K, Kakegawa S, Ohtaki Y, Nagashima T, Kaira K, Horiguchi J, Oyama T, Takeyoshi I: Prognostic significance of aromatase and estrogen receptor beta expression in EGFR wild-type lung adenocarcinoma. Am J Transl Res 8: 81-97, 2016

Yajima R, Yajima T, Fujii T, Yanagita Y, Fujisawa T, Miyamoto T, Tsutsumi S, Iijima M, Kuwano H. Tumor-infiltrating CD45RO(+) memory cells are associated with a favorable prognosis breast cancer. Breast Cancer. 23:668-74, 2016

Yazawa T, Kaira K, Shimizu K, Shimizu A, Mori K, Nagashima T, Ohtaki Y, Oyama T, Mogi A, Kuwano H: Prognostic significance of β2-adrenergic receptor expression in non-small cell lung cancer. Am J Transl Res 8: 5059-70, 2016.

Atsumi J, Hanami T, Enokida Y, Ogawa H, Delobel D, Mitani Y, Kimura Y, Soma T, Tagami M, Takase Y, Ichihara T, Takeyoshi I, Usui K, Hayashizaki Y, Shimizu K: Eprobe-mediated screening system for somatic mutations in the KRAS locus. Oncol Rep 33: 2719-27, 2015

Azuma Y, Yokobori T, Mogi A, Altan B, Yajima T, Kosaka T, Onozato R, Yamaki E, Asao T, Nishiyama M, Kuwano H. SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer. J Surg Oncol　112:231-7, 2015

Igai H, Kamiyoshihara M, Kawatani N, Ibe T, Shimizu K: A case report: right upper lobectomy with middle lobe preservation after right lower lobectomy. Surg Case Rep 1: 19, 2015

Kaira K, Arakawa K, Shimizu K, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Takeyoshi I: Relationship between CD147 and expression of amino acid transporters (LAT1 and ASCT2) in patients with pancreatic cancer. Am J Transl Res 7: 356-63, 2015

Kaira K, Sunose Y, Arakawa K, Sunaga N, Shimizu K, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Takeyoshi I: Clinicopathological significance of ASC amino acid transporter-2 expression in pancreatic ductal carcinoma. Histopathology 66: 234-43, 2015

Kamiyoshihara M, Igai H, Ibe T, Kawatani N, Shimizu K, Takeyoshi I: A 3.5-cm Single-Incision VATS Anatomical Segmentectomy for Lung Cancer. Ann Thorac Cardiovasc Surg 21: 178-82, 2015

Kuranami S, Yokobori T, Mogi A, Altan B, Yajima T, Onozato R, Azuma Y, Iijima M, Kosaka T, Kuwano H. Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer. Anticancer Res 35: 2411-5, 2015

Kuwako T, Imai H, Masuda T, Miura Y, Seki K, Yoshino R, Kaira K, Utsugi M, Shimizu K, Sunaga N, Tomizawa Y, Ishihara S, Ishizuka T, Mogi A, Hisada T, Minato K, Takise A, Saito R, Yamada M: First-line gefitinib treatment in elderly patients (aged ≥75 years) with non-small cell lung cancer harboring EGFR mutations. Cancer Chemother Pharmacol 76: 761-9, 2015

Masuda T, Imai H, Kuwako T, Miura Y, Yoshino R, Kaira K, Shimizu K, Sunaga N, Tomizawa Y, Ishihara S, Mogi A, Hisada T, Minato K, Takise A, Saito R, Yamada M: Efficacy of platinum combination chemotherapy after first-line gefitinib treatment in non-small cell lung cancer patients harboring sensitive EGFR mutations. Clin Transl Oncol 17: 702-9, 2015

Mogi A, Yajima T, Tomizawa K, Onozato R, Tanaka S, Kuwano H. Video-Assisted Thoracoscopic Surgery after Preoperative CT-Guided Lipiodol Marking of Small or Impalpable Pulmonary Nodules. Ann Thorac Cardiovasc Surg 21:435-9, 2015

Nagashima T, Shimizu K, Ohtaki Y, Obayashi K, Kakegawa S, Nakazawa S, Kamiyoshihara M, Igai H, Takeyoshi I: An analysis of variations in the bronchovascular pattern of the right upper lobe using three-dimensional CT angiography and bronchography. Gen Thorac Cardiovasc Surg 63: 354-60, 2015

Yazawa T, Shimizu K, Kaira K, Nagashima T, Ohtaki Y, Atsumi J, Obayashi K, Nagamori S, Kanai Y, Oyama T, Takeyoshi I: Clinical significance of coexpression of L-type amino acid transporter 1 (LAT1) and ASC amino acid transporter 2 (ASCT2) in lung adenocarcinoma. Am J Transl Res 7: 1126-39, 2015

Enokida Y, Shimizu K, Kakegawa S, Atsumi J, Takase Y, Miyamae Y, Nagashima T, Ohtaki Y, Kaira K, Sunaga N, Yanagitani N, Yoshino R, Tsunekawa K, Igai H, Kamiyoshihara M, Usui K, Lezhava A, Tomizawa Y, Ishikawa T, Murakami M, Hayashizaki Y, Takeyoshi I: Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk. Biomed Rep 2: 719-24, 2014

Igai H, Kamiyoshihara M, Kawatani N, Ibe T, Shimizu K: Sternal intraosseous schwannoma mimicking breast cancer metastasis. J Cardiothorac Surg 9: 116, 2014

Igai H, Kamiyoshihara M, Nagashima T, Ohtaki Y, Shimizu K: A resectable pancreatic metastasis from pulmonary adenocarcinoma. Ann Thorac Cardiovasc Surg 20: 243-5, 2014

Igai H, Kamiyoshihara M, Kawatani N, Ibe T, Shimizu K: Thoracoscopic caudal left lower lobectomy in a patient with fused fissure. Asian J Endosc Surg 7: 342-4, 2014

Igai H, Kamiyoshihara M, Ibe T, Kawatani N, Shimizu K: Single-incision thoracoscopic surgery for spontaneous pneumothorax using multi-degrees of freedom forceps. Ann Thorac Cardiovasc Surg 20: 974-9, 2014

Kamiyoshihara M, Igai H, Kawatani N, Ibe T, Tomizawa N, Obayashi K, Shimizu K, Takeyoshi I: Lung metastasectomy for postoperative colorectal cancer in patients with a history of hepatic metastasis. Gen Thorac Cardiovasc Surg 62: 314-20, 2014

Kamiyoshihara M, Ibe T, Igai H, Kawatani N, Hayashi H, Shimizu K, Takeyoshi I:       Profuse mediastinal hemorrhage due to mediastinitis after a sternal infection. Ann Thorac Cardiovasc Surg 20: 629-31, 2014

Nakazawa S, Mohara J, Takahashi T, Koike N, Takeyoshi I. Aortocaval fistula associated with ruptured abdominal aortic aneurysm. Ann Vasc Surg. 28: 1793.e5-9, 2014.

Ohtaki Y, Shimizu K, Kakegawa S, Nagashima T, Nakano T, Atsumi J, Enokida Y, Igai H, Ibe T, Sugano M, Kamiyoshihara M, Kawashima O, Kaira K, Sunaga N, Takeyoshi I: Postrecurrence survival of surgically resected pulmonary adenocarcinoma patients according to EGFR and KRAS mutation status. Mol Clin Oncol 2: 187-96, 2014

Ohtaki Y, Shimizu K: Anatomical thoracoscopic segmentectomy for lung cancer. Gen Thorac Cardiovasc Surg 62: 586-93, 2014

Shimizu K, Kaira K, Tomizawa Y, Sunaga N, Kawashima O, Oriuchi N, Tominaga H, Nagamori S, Kanai Y, Yamada M, Oyama T, Takeyoshi I: ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer. Br J Cancer 110: 2030-9, 2014

Shimizu K, Nagashima T, Ohtaki Y, Takeyoshi I: Novel repair of a defect in the cervical trachea with a thymus pedicle flap. J Thorac Cardiovasc Surg 147:1988-90, 2014

Sunaga N, Kaira K, Tomizawa Y, Shimizu K, Imai H, Takahashi G, Kakegawa S, Ohtaki Y, Nagashima T, Kasahara N, Kawashima O, Hisada T, Saito R, Yamada M: Clinicopathological and prognostic significance of interleukin-8 expression and its relationship to KRAS mutation in lung adenocarcinoma. Br J Cancer 110: 2047-53, 2014

Yashima H, Shimizu K, Araki T, Aomori T, Ohtaki Y, Nagashima T, Enokida Y, Atsumi J, Nakamura T, Takeyoshi I, Yamamoto K: Assessment of DDR2, BRAF, EGFR and KRAS mutations as therapeutic targets in non-adenocarcinoma lung cancer patients. Mol Clin Oncol 2: 714-8, 2014

Yokobori T, Yokoyama Y, Mogi A, Endoh H, Altan B, Kosaka T, Yamaki E, Yajima T, Tomizawa K, Azuma Y, Onozato R, Miyazaki T, Tanaka S, Kuwano H. FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs. Mol Cancer Res 12:32-7, 2014

Ando H, Shitara Y, Mogami Y, Kobayashi T, Yajima T, Tani M, Morinaga N, Ishizaki M, Hashimoto S, Nakabayashi T, Kuwano H. A long-term survival case of rectal cancer with multiple pulmonary metastases treated with multidisciplinary chemotherapy. Int Surg 98:311-4, 2013

Atsumi J, Shimizu K, Nakano T, Kakegawa S, Sano T, Katano M, Hiroshima K, Takeyoshi I:  A peculiar squamous dysplastic lesion presenting as a ground-glass opacity: a case report.    Eur Respir J 41: 1228-30, 2013

Enokida Y, Shimizu K, Atsumi J, Lezhava A, Tanaka Y, Kimura Y, Soma T, Hanami T, Kawai Y, Usui K, Okano Y, Kakegawa S, Ogawa H, Miyamae Y, Miyagi Y, Nakayama H, Ishikawa T, Hayashizaki Y, Takeyoshi I: Rapid detection of SNP (c.309T>G) in the MDM2 gene by the Duplex SmartAmp method. PLoS One 8: e60151, 2013

Igai H, Kamiyoshihara M, Nagashima T, Ohtaki Y, Shimizu K: A new application of a wound retractor for chest wall surgery. Gen Thorac Cardiovasc Surg 61: 53-4, 2013

Nakano T, Shimizu K, Nakano S, Takeyoshi I: Usefulness of three-dimensional computed tomographic angiography with bronchography for the planning of minimally invasive video-assisted thoracic surgery for intralobar pulmonary sequestration. Eur J Cardiothorac Surg 43: 199, 2013

Ohtaki Y, Shimizu K, Nagashima T, Nakano T, Takeyoshi I: Posterior mediastinal malignant lymphoma mimicking a neurogenic tumor. Ann Thorac Surg 95: e49, 2013

Tanaka K, Shimizu K, Ohtaki Y, Nakano T, Kamiyoshihara M, Kaira K, Rokutanda N, Horiguchi J, Oyama T, Takeyoshi I: Diagnosis and surgical resection of solitary pulmonary nodules in patients with breast cancer. Mol Clin Oncol 1: 117-23, 2013

Yajima T, Onozato R, Shitara Y, Mogi A, Tanaka S, Kuwano H. Relapsed cervicomediastinal lymph node carcinoma with an unknown primary site treated with TS-1 alone: a case report. BMC Res Notes 6:558, 2013

Yamaki E, Yajima T, Kosaka T, Mogi A, Tanaka S, Kuwano H. Podoplanin overexpression in human mesothelioma cell lines enhances the tumorigenic phenotype. Oncol Rep 29:932-40, 2013

|　和文論文・著書

上吉原光宏, 井貝仁, 吉川良平, 大沢郁, 矢澤友宏, 清水公裕, 茂木晃, 調憲 : 【肺癌縮小手術の適応とその成績】原発性非小細胞肺癌に対する消極的縮小手術（非解剖学的肺切除）の治療成績. 胸部外科, 72: 4-10, 2019

上吉原光宏, 井貝仁, 伊部崇史, 大沢郁, 吉川良平, 清水公裕, 茂木晃, 調憲, 桑野博行 : 【肺癌の集学的治療の現況】再発肺癌における集学的治療 原発性肺癌術後再発例に対する集学的治療. 胸部外科, 7: 302-310, 2018

上吉原光宏, 井貝仁, 伊部崇史, 河谷菜津子, 内山壽夫, 五味暁憲, 高橋紗也子, 大竹弘哲, 清水公裕, 茂木晃, 桑野博行 :【呼吸器・食道手術周術期における口腔ケアとリハビリテーションの現状】口腔・嚥下機能の管理 肺悪性腫瘍手術における周術期口腔機能管理および医科・歯科連携の有用性. 胸部外科, 69: 4-11, 2016

上吉原光宏，河谷菜津子，大沢郁，吉川良平，二宮洋，清水公裕，茂木晃，桑野博行 : 気管切開術後気道狭窄に対して集学的治療が奏効した1例．日気管食道会報, 67:    429-438, 2016

懸川誠一，川島修，富澤由雄，菅野雅之，清水公裕 : 完全内臓逆位に合併した原発性肺癌に対する内視鏡下区域切除. 胸部外科, 69, 521-524. 2016

河谷菜津子，上吉原光宏，井貝仁，伊部崇史，清水公裕 : 緊急胸腔鏡手術を施行した特発性血気胸の1例 本邦報告例を加えての検討．日胸臨, 74: 1397-1401, 2015

清水公裕：よく使用する器具・機械。岡田守人（編）呼吸器外科の手術看護パーフェクトマニュアル pp23-46、メディカ出版、大阪、2015

清水公裕 : まい・てくにっく 心膜周囲脂肪織による気管支断端被覆 胸部外科, 68: 975, 2015

上吉原光宏, 井貝仁, 伊部崇史, 河谷菜津子, 清水公裕, 竹吉泉 : 手術の工夫 単孔式完全胸腔鏡下肺葉切除. 胸部外科, 67: 540-543, 2014

川島修, 懸川誠一, 永島宗晃, 伊部崇史, 中野哲宏, 清水公裕 :【胸壁・横隔膜の手術-その1】診断 胸壁原発腫瘍に対する外科治療の現状. 胸部外科, 67: 9-14, 2014

清水公裕：先天性肺疾患。岡田守人（編）呼吸器外科の術前術後ケア　pp193-203、メディカ出版、大阪、2014

清水公裕 : 呼吸器外科領域での3DCT・3Dプリンターの利用法. 日本医事新報,     4729: 49-50, 2014

清水公裕 : 肺癌手術におけるエネルギーデバイスの特徴と使いわけ.日本医事新報, 4728: 65-66, 2014

清水公裕 : 気管・気管支血流に配慮した気道再建術. 手術, 68: 1127-1135, 2014

上吉原光宏, 井貝仁, 伊部崇史, 河谷菜津子, 安東立正, 富澤直樹, 大滝容一, 渥實潤, 中澤世識, 尾林海, 清水公裕, 竹吉泉 :【転移性肺腫瘍の外科治療】大腸癌術後肝転移を既往に もつ転移性肺腫瘍切除例の検討. 胸部外科, 66: 291-297, 2013